Patrick Dempsey is leaving Grey’s Anatomy, reports CTV.

The actor, known as ‘McDreamy’ on the show, says the current season of the hit show will be “his last.”

The 45-year-old has played Dr. Derek Shepherd in the medical drama since 2005, acting both as an authoritative figure and love interest to Dr. Meredith Grey, played by Ellen Pompeo.

Dempsey says he has no plans to continue with the role once season eight ends, but does admit the end of his contract is “bittersweet.”

He told Italy’s ‘Vanity Fair’ magazine: “It’s gonna be my last. I do not know what’s going to happen to the other characters, but for me it’s done.”

“[Leaving will be] bittersweet because it’s been a great part of my life. But I can’t see me doing it anymore.”

Dempsey’s publicist, though, is denying the that the departure is sure thing.

The representative said in a statement: “He was referring to the fact that his contract is up at the end of next season and we have no idea what the future holds.”

Meanwhile, Pompeo has also revealed her contract will also end next season, and it is unlikely she will renew it. If both these characters leave the show, I have a feeling it will tank. Hardcore.

I know a lot of people who still watch it, and with the two main characters leaving, everyone will be pissed. It’s better to just end the show on a high note than slowly kill it.

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Despite rumours that Katherine Heigl’s character Izzie Stevens will have a brain tumour in the upcoming season of “Grey’s Anatomy,” executive producer Shona Rhimes says the news is not true.

According to E! News, Rhimes says that although Izzie won’t undergo any personal medical crisis, “interesting sparks” will fly between Alex and Izzie – following their season finale hook-up.

But will other fan favourites Meredith and McDreamy finally settle down?

Not quite yet. “It’s really exciting to see what’s going to come next and how [Meredith's] going to deal with living with a boy, and all the things a man like Derek, who has been married and is a grown-up, might expect,” says Rhimes.

Rhimes continues to say that a new romance fans should keep their eyes on is Callie and Erica’s. “They are definitely on a journey, and it’s going to be a really interesting one…also both actresses are so game; they’re so willing to do something.”

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