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After 15 seasons, NBC’s groundbreaking medical drama “ER” checked out for the last time Thursday – and fans turned out in droves to say goodbye.

According to Nielsen estimates, the two-hour series finale was seen by 16.2 million viewers, the show’s largest audience in nearly three years.

It was also the most-watched drama series finale since CBS’ “Murder She Wrote” bowed out in 1996 with 16.5 million viewers.

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Four new interns will report to “ER” for its upcoming final season.

Shiri Appleby, Julian Morris, Emily Rose and Victor Rasuk have landed recurring roles on the medical drama as young doctors at County General Hospital, according to The Hollywood Reporter.

Appleby, best known for starring in the teen drama “Roswell,” will play the smart and eager Daria Wade.

Morris, whose credits include the upcoming “Valkyrie” with Tom Cruise, will play Daria’s brother Andrew, who “uses his looks, smarts and charm to get ahead,” says THR.

Rose, who has appeared in “Brothers & Sisters” and “Jericho,” was cast as the ambitious Tracy Martin, whose penchant for controlling things gets her in trouble with her superiors.

Finally, Rasuk will play Ryan Sanchez, a married, native New Yorker who is described as “a tad nervous.”

The four join previously announced cast addition Angela Bassett, who will have a regular role in the upcoming season, as well as returning ‘”ER” alum Noah Wyle, who will appear as Dr. John Carter in at least four of the season’s planned 19 episodes.

“ER,” which is entering its 15th and final season, has won 22 Emmy Awards during its run including Outstanding Drama Series in 1996.