Sean Penn is going from Oscar to Stooge.

The “Milk” actor, who picked up his second Academy Award last month, has been cast as the violin-toting Larry in “The Three Stooges,” the Farrelly Brothers’ upcoming MGM comedy.

The movie will not be a biopic, but rather a modern take on the slapstick trio based on their classic film shorts.

And Penn isn’t the only big name attached to the MGM project. Variety reports that Jim Carrey is in final negotiations to play Curly – and is even planning to gain 40 pounds to play the rotund Stooge.

The studio is also reportedly pursuing Penn’s “21 Grams” co-star Benicio Del Toro to play the nose-tweaking, ear-twisting Moe.

The movie, which will be written and directed by Bobby and Peter Farrelly (“Dumb and Dumber,” “There’s Something About Mary”) is scheduled to begin production in early fall for a 2010 release.

The Three Stooges starred in nearly 200 shorts and movies between 1930 and 1975 and are best remembered for their physical slapstick comedy and snappy one-liners.

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andPOP caught up with one of the coolest men on the planet, Benicio Del Toro, during the Toronto Film Fest.

Del Toro was promoting his new flick “Guerrilla” – he plays Che Guevara – and we spoke with him and Lou Diamond Phillips at the film’s after party.

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Read more at andPOP. andPOP - POP Culture with Substance