Born in Queens, New York, Harris began her acting career in the early 80's with a few television spots. She celebrated her 11th birthday on the set of Halloween 4, her first feature role.
Danielle would go on to appear films such as City Slickers, The Last Boy Scout, Wish Upon a Star, and Urban Legend. She had a recurring role on the sitcom Roseanne as the teen neighbor Molly.
In the mid-1990s, she was stalked by an obsessed fan, who wrote letters threatening to kill her. He was later arrested after bringing a shotgun to her home.
Harris has recently taken on several voice acting roles, including that of Debbie on the animated series The Wild Thornberrys, Sierra in Father of the Pride.
From 2000 to 2002 she appeared in the CBS television drama That's Life. Danielle starred in the 2004 production, Debating Robert Lee. Her most recent film is Race You to the Bottom (2005).